Cognitively, rabbits with hypercholesterolemia-induced AD display age-dependent deficits in associative learning that closely parallel those observed in humans. As measured by impairment of eyeblink classical conditioning, these deficits are beyond those observed with normal aging, are specific to AD (i.e., not observed in Parkinson’s Disease or Huntington’s disease), and are relieved upon administration of drugs that improve cognition. No other experimental animal model of AD boasts such an extensive body of existing data by which to judge cognitive impairment as the classically-conditioned eye blink response of rabbits.