IntroductionThe presence of trace levels of antibiotics in the environmental system has concerned to developed regions as well as international organizations. These bioactive compounds have been found in various types of environmental matrices, such as soil, surface and ground water . They can enter to the environment after excreted by animals and accidentally released during manufacturing and discarding. In general, veterinary medicines cannot be fully metabolized by physiological pathways in animals.For several veterinary antibiotics, metabolite rates are very low(<10%), and the non-metabolite antibiotics are directly excreted through urine and face.Metabolites of the medical compounds can still have bioactivity, and may bring negative effects on aquatic and terrestrial ecosystems.The collected manure from husbandry is used as organic fertilizer,and is a major source of antibiotics in agricultural regions.As an important group of veterinary pharmaceuticals,sulfonamide antibiotics have intensively been studied with respect to their occurrence and fate in environmental matrices. The majorityof studies have attested the general presence of sulfonamides in soils from ng/L up to mg/L level and at relatively low levels in water. For example, sulfadimethoxine was detected up to mg/kg leve
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