As a result, the syntheses
of PG were inhibited subsequently
contributing to the observed antiinflammatory,
antipyretic and analgesic activities. In
addition, spilanthol has been shown to reduce
NO release and thereby inhibit inflammatory
mediators and attenuating the
expression of COX-2 and iNOS. This
could be attributed to the immunostimulant
activity of S. acmella in its traditional usages.