Cissampelos pareira is a woody climbing vine with leaves up to one foot long and it belongs to the family Menispermaceae and genus Cissampelos. It is found throughout the tropical region of India and Bangladesh. The parts of the plant used for medicinal effect are whole vine, seed, bark and leaf[1]. The leaves of the plant contain alkaloids like tetrandrine, which has analgesic effect and has recently been shown to have antitumor and antileukemic properties as well. The roots and stem contain the bisbenzylisoquinoline alkaloids that have been demonstrated as antiinflammatory agent[1]. Traditionally C. pareira has been used in numerous medical conditions like pain, fever, diarrhea and infection. C. pareira is thought to be responsible for many of its properties like antioxidant and anti-inflammatory[1,2]. The present study was undertaken aiming to find out the detailed phtyochemicals as well as analgesic and antiinflammatory activity of ethanol extract of C. pareira using in vivo model.