The vascular system of the skin of the human body has
regional heterogeneity in the structure and functional
organization that forms complex interwoven "body carpet".
The skin blood flow is known to change in a wide range
mostly according to the thermal state of the organism [1], [2],
[3]. Thus, skin blood flow increases during heat elimination
and it significantly decreases during heat conservation.
Vessels of the most distal parts of the body, such as fingers,
toes and tips of the nose and ears, are supplied by unique
structural and functional features that prevent their from total
blood flow abruption in order to maintain nutritional perfusion
[3]. The control of the thermoregulatory vasomotor reactions
includes manifold factors such as neuro-humoral and
endothelial ones that interplay with other homeostatic
mechanisms. Whole-body cooling during exposure to cold
environment increases sympathetic adrenergic outflow to skin
vessels that induces the vasoconstriction effect [1], [3]. Local
cooling of the skin directly amplifies sympathetically