Neonatal sepsis is a life-threatening infection of the newborn. Zaidi's study found that treatment failure was significantly higher with trimethoprim-sulfamethoxazole (TMP-SMX)-GM as compared with PEN-GM, and the outpatient therapy with injectable antibiotics is an effective option when hospitalization of sick infants is unfeasible.Procaine PEN-GM was superior to TMP-SMX-GM. Ceftriaxone is more expensive, and may be less effective. Also, PEN or ampicillin sepsis as compared to other antibiotics.However, limited sample sizes and poor evidence suggest that further research is required to support this conclusion.