In addition to this apparent recovery, which for some
measures requires relatively long time periods after
exposure to an acute binge, we found that some of the
METH-induced effects measured three days after exposure
to the binge, were significantly reduced by ED pretreatment:
the binge-induced decrease in DA levels was attenuated and
the reduction in DAT binding was completely blocked.
These findings are consistent with other studies showing
that various acute METH binge effects on DA pathways are
diminished by prior METH treatment.