English:
Protaglandins have protective effect on the gastric mucosa. a NSAIDs are a common cause of peptic ulceration and bleeding in (PUB). PUB may occur in the absence of any dyspeptic symp- toms. NSAIDs should be avoided in any patient with active peptic is ulceration or a past history of PUB. Approximately 5% of asthmatics exhibit aspirin-induced d asthma (AIA) and it is likely that there is cross-reactivity with n NSAIDs. This problem is more common in adult-onset asthma associated with nasal polyps rather than the juvenile form. NSAIDs should be avoided in any patient with AIA and be used with caution in any asthmatic who has not previously been exposed to these drugs. Prostaglandins have a role in the maintenance of renal blood flow. Short-term use of NSAIDs in healthy subjects may produce a temporary effect on renal function. NSAIDs should be avoided or used with caution in patients with renal dysfunction or at risk of developing renal dysfunction, for example significant blood loss. Renal function should be checked regularly cyclo oxygenase exists in two forms. Coxi and cox2. cox is the constitutive form of the enzyme and is responsible for the housekeeping functions of prostaglandins (platelet aggregation. gastric protection and renal perfusion). COX2 is an inducible form of the enzyme that is triggered by stimuli such as tissue injury. It is largely responsible for the pain and inflammatory effects of prostaglandins. The discovery of these different forms led to the development of drugs that selectively inhibit cox2. coX2 inhibitors do not produce more endoscopically diagnosed peptic ulcers than placebo and do not prolong bleeding time. Adverse effects on asthma and renal function may be less than