Medicinal plants have gained much interest in the prevention and treatment of common human diseasesuch as cold and fever, hypertension and postpartum. Bioactive compounds from medicinal plants weresynthesised using effective extraction methods which have important roles in the pharmaceutical product development. Orthosiphon aristatus (OA), Eurycoma longifolia (EL) and Andrographis paniculata (AP)are among popular medicinal herbs in Southeast Asia. The major compounds for these medicinal plantsare polar bioactive compounds (rosmarinic acid, eurycomanone and andrographolide) which have multiple benefits to human health. The bioactive compounds are used as a drug to function against a varietyof diseases with the support of scientific evidence. This paper was intended to prepare a complete reviewabout the extraction techniques (e.g. OA, EL and AP) of these medicinal plants based on existing studiesand scientific works. Suitable solvents and techniques to obtain their major bioactive compounds andtheir therapeutic potentials were discussed.