They are rich source of secondary metabolites with diverse biological activity. Being a large group of microbial resources of wide practical use and high commercial value, actinomycetes contribute to around 70% of the source of antibiotics and also produce numerous non-antibiotic bioactive metabolites, such as enzymes, enzyme inhibitors, immunological regulators, anti-oxidation reagents, and so on. Actinomycetes are widely distributed in natural habitats, especially soil and ocean