An emerging theme in cancer is that
that oncogenic gene alterations reprogram
the metabolic network, thus enabling tumorigenesis
(20). Cdh1 displays tumor
suppressor activity, as supported by its
down-regulation or the inactivation
of APC/CCdh1 observed in human cancers
(10, 13). It will be worthwhile to test if
deregulation or mutations of Cdh1 or certain
substrates contributes to alterations in
cell metabolism pathways, leading to malignant
transformation of the cells.