Wastewater from chemical synthesis processes of the pharmaceutical industry often seasonally changes in character, quantity (Arslan and Akmehmet Balcioglu, 2002), and also contains spent solvents, additives, reactants and small amounts of intermediates and products which results in high load of chemical oxygen demand (COD) that is recalcitrant to conventionally aerobic/anaerobic treatment (Fent et al., 2006 and Oktem et al., 2007). Previous reports indicated that the