The aim of this present study was isolation of Vibrio sp which was present in the prawn seafood (Penaeus monodon) and some preservation techniques have been employed to reduce the growth of Vibrio. Sp such as drying, radiation, organic acid and osmotic pressure. There is a limited range of techniques currently employed to preserve food. The drying of fish is a well-understood physical process. Microbial spoilage can be reduced by drying. Radiation is effective for ensuring the microbiological safety of food naturally contaminated by Vibrio sp [15]. NaCl stimulates the growth of all species and is an obligate requirement for some.