ABSTRACT
The purpose of this article is to provide a general review of the current literature on
the factors associated with the outcomes of hospitalizations, survival and healthrelated
quality of life in acute exacerbations of chronic obstructive pulmonary disease
(AECOPD), highlighting the limitations and the complexities in interpretation of the
results of current studies. There is no consensus definition for AECOPD; onsets may
be difficult to define and the determination of duration elusive. The prevalence of
acute exacerbations of COPD (AECOPD) in the community appears to be
underestimated as exacerbations are underreported by patients and their doctors.
Hospitalization for COPD is due mainly to severe AECOPDs which drive the cost of
care. There are few longitudinal epidemiological studies on factors associated with
hospitalizations for AECOPD. The results of current studies do not allow clear
differentiation between associations that are predictors of event, the consequences of
the event, or indicators of severity. Strategies to reduce severe exacerbations of COPD
include pharmacological treatment, vaccinations, pulmonary rehabilitation, and home
care programs. The optimal strategy for the reduction of hospitalization in COPD
remains unclear. Long-term interventional studies are needed to provide clearer
information for the prevention of exacerbations and hospitalizations in COPD.
Key Words: Chronic obstructive pulmonary disease; AECOPD; Acute exacerbations;
Outcomes.
ABSTRACTThe purpose of this article is to provide a general review of the current literature onthe factors associated with the outcomes of hospitalizations, survival and healthrelatedquality of life in acute exacerbations of chronic obstructive pulmonary disease(AECOPD), highlighting the limitations and the complexities in interpretation of theresults of current studies. There is no consensus definition for AECOPD; onsets maybe difficult to define and the determination of duration elusive. The prevalence ofacute exacerbations of COPD (AECOPD) in the community appears to beunderestimated as exacerbations are underreported by patients and their doctors.Hospitalization for COPD is due mainly to severe AECOPDs which drive the cost ofcare. There are few longitudinal epidemiological studies on factors associated withhospitalizations for AECOPD. The results of current studies do not allow cleardifferentiation between associations that are predictors of event, the consequences ofthe event, or indicators of severity. Strategies to reduce severe exacerbations of COPDinclude pharmacological treatment, vaccinations, pulmonary rehabilitation, and homecare programs. The optimal strategy for the reduction of hospitalization in COPDremains unclear. Long-term interventional studies are needed to provide clearerinformation for the prevention of exacerbations and hospitalizations in COPD.Key Words: Chronic obstructive pulmonary disease; AECOPD; Acute exacerbations;Outcomes.
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