Several methods can be approached to modify the physico-chemical properties of the Active Pharmaceutical ingredients. Here in
this research work the designated supramolecular synthon approach, with a strategy to exploit acid-amide and acid-chloride
heterosynthons has been used to prepare Aceclofenac-Nicotinamide molecular complexes. The molecular complexes were
prepared by neat grinding (ACF-NI NG) and solution crystallization methods with DMSO as solvent (ACF-NI). FTIR, DSC,
Mass analysis and SEM has been used to study the prepared molecular complexes. The results conclude the successful formation
of the ACF-NI and ACF-NI NG molecular complexes. Appearance of single DSC endothermic peak and in the FT-IR results,
changes observed in the vibrational frequencies associated with amide, acid and chloride groups of the reactants prove to be
effective diagnostic features to confirm the formation of molecular complexes.