Abbreviations
ASK1: apoptosis signal-regulating kinase 1; Bcl-2: B-cell lymphoma 2; COX-2: cyclooxygenase-2; DCFDA: 2',7'-dichlorofluorescein diacetate; ER: estrogen receptor; ERK: extracellular signal-regulated kinase; GFP: green fluorescent protein; HER2: human epidermal growth factor receptor-2; HPLC: high-performance liquid chromatography; IC50: concentration that inhibits cell growth by 50%; JNK: Jun N-terminal kinase; Lipo-P-I: liposome-encapsulated phospho-ibuprofen; MAPK: mitogen-activated protein kinase; Mcl-1: myeloid cell leukemia 1; MTT: methylthiazolyldiphenyl-tetrazolium bromide; NAC: N-acetyl-cysteine; NF: nuclear factor; NSAID: nonsteroidal anti-inflammatory drug; O2-: superoxide anion; PAGE: polyacrylamide gel electrophoresis; P-I: phospho-ibuprofen; PCR: polymerase chain reaction; RONS: reactive oxygen and nitrogen species; shRNA: short hairpin RNA; siRNA: small interfering RNA; Trx: thioredoxin; Trx-1: thioredoxin-1; TrxR: thioredoxin reductase; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.