Cassava is a major food crop for approximately 700 million people, especially in African countries. A large quantity of waste is produced after processing of cassava, mainly consisting of tuber peels. Although previous research has shown that these peels can be an ingredient for substrate to cultivate mushrooms, yields were usually inferior compared to traditional substrates such as saw dust. In a project funded by the European Union (http://www.fp7-gratitude.eu/) trials were done for the production of oyster mushrooms using fermented peels and stems from cassava crop produced in Ghana. Four mushroom strains representing two species (Pleurotus ostreatus and P. pulmonarius) were grown on fermented substrates made from cassava waste (peels & stems) without further heating/sterilisation. Peels and cassava stems were tested in different ratio’s and supplemented with different amounts of rice or wheat bran. All the substrate samples colonized quickly (15-16 days) and time for pinning varied between 18 and 24 days. The P. pulmonarius strains produced three flushes within 47 days (starting from inoculation) and the P. ostreatus strains needed 57-63 days completing flush 3. Biological efficiencies after 3 flushes varied between 38% and 100%. The effect of bran supplementation on yields depended on the concentration (0, 1, 6 and 12% w/w), type of bran (rice or wheat) and strain used. The trials have shown that cassava waste (stems and peels) can be used well for the production of oyster mushrooms and that substrates containing up to 75% cassava peels have productions well comparable to yields obtained on the traditional saw dust based substrates.