β –Thalassemia
Worldwide, thalassemia is a common genetic disorder affecting over 100,00 individuals (Rndolph, 2004). The term thalassemia comes from the Greek word thalassa, meaning “sea,” is spplied to a variety of inherited blood disorder characterized by deficiencies in the rate of production of specific globin chains in hemoglobin. The name appropriately refer to people living near the Mediterranean Sea, namely Italians, Greeks, and Syrians, or to their descendants. Evidence suggests that the high incidence of the disorder among these group is a result of selective advantage of the trait in protecting against malaria, as is postulared for sickle cell disease. The disorder has a wide geographic distribution, however, probably as a result of genetic t though intermarriages or possibly as a result of spontaneous mutation.
The thalassemia are classified according to the hemoglobin chain affected and the amount of the globin chain that is synthesized. The two major categories are α-thalassemia andβ – thalassemia. Thaslasemia is seen in vatious population group, such as Asians, African-American, Italians, and inhabitanes of the Middle F astern regions, and the majority of births of affected individuals occur in these groups (Cohen, Galanello, Rennell, and others, 2004).
β –Thalassemia
Worldwide, thalassemia is a common genetic disorder affecting over 100,00 individuals (Rndolph, 2004). The term thalassemia comes from the Greek word thalassa, meaning “sea,” is spplied to a variety of inherited blood disorder characterized by deficiencies in the rate of production of specific globin chains in hemoglobin. The name appropriately refer to people living near the Mediterranean Sea, namely Italians, Greeks, and Syrians, or to their descendants. Evidence suggests that the high incidence of the disorder among these group is a result of selective advantage of the trait in protecting against malaria, as is postulared for sickle cell disease. The disorder has a wide geographic distribution, however, probably as a result of genetic t though intermarriages or possibly as a result of spontaneous mutation.
The thalassemia are classified according to the hemoglobin chain affected and the amount of the globin chain that is synthesized. The two major categories are α-thalassemia andβ – thalassemia. Thaslasemia is seen in vatious population group, such as Asians, African-American, Italians, and inhabitanes of the Middle F astern regions, and the majority of births of affected individuals occur in these groups (Cohen, Galanello, Rennell, and others, 2004).
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