some AMPs can also inhibit proteases of microbes. For example, histatin 5 stop the periodontal tissue destruction by inhibiting a protease from Bacteriocides gingivalis and eNAP-2 has anti-protease activities against microbial serin proteases [137]. Interestingly, there are some intracellular AMPs which can only kill cells at certain growth stages. For example, diptericin is only effective against actively growing bacterial cells, suggesting it may interact with certain specific metabolic pathways during bacterial growth. Among these intracellularly active AMPs, some of them have multiple targets. For example seminalplasmin inhibits RNA polymerase and can stop RNA synthesis completely at concentrations lower than many other antibacterial agents. On the other hand, the same AMP can activate an autolysin protein inside the target cells leading to autolysis.