Indigenous medicinal plants have great medicinal potentials, as they have been used and are still in use for the management
of several ailments and as nutritional supplements. The medicinal efficacy of medicinal plants is highly depended on the
method of extraction or extract preparation. The present study evaluates the preparation of crude extracts from the root bark
and stem bark of three plants with medicinal potentials – Vernonia amygdalina, Nauclea latifolia and Gongronema latifolium
– using 80% ethanol as solvent and standard laboratory equipment. The result showed a high (%) yield of 13.6 and 11.96
respectively for root bark and stem bark of Vernonia amygdalina, 10.75 and 10.01 respectively for root bark and stem bark of
Gongronema latifolium and 19.90 and 18.30 respectively for root and stem bark of Nauclea latifolia. These extracts were
used for various analysis such as proximate and phytochemicals and the results agreed with those of the extracts of the same
plants using other standard methods. Also, the extracts were used for toxicity, anti-diabetic and anti-hypertensive screening
and were found to be of high efficacy