Characteristics of the Cohort and Subsequent Neoplasms
As of January 1, 2006, 802 SNs and SMNs, excluding NMSC, have been diagnosed in 730 CCSS participants. Four survivors had three SMNs, 64 survivors had two SMNs, and 662 survivors had one SMN. There were 1,007 cases of NMSC among 493 survivors, of whom 430 had NMSC without another SMN. Sixty-six individuals have had a meningioma. The characteristics of the CCSS cohort with regard to SMNs or NMSC are shown in Table 1. Patients with an SMN or NMSC were older at the time of their childhood cancer diagnosis, and most were survivors of HL who were treated with radiotherapy.