This action of gingerols was attributed to facilitation of insulin-independent glucose uptake by increasing translocation of glucose transporter GLUT4 to the muscle cell plasma membrane surface, together with small increases in total GLUT4 protein expression (1). Another mechanism for reducing blood glucose by ginger hydroalcoholic extract, is the inhibition of hepatic phosphorylase enzyme, hereby it prevents the breakdown of hepatic glycogen storages, also, can increases the activity of enzymes improving glycogen synthesis.