Multiple studies have demonstrated the association between inappropriate antimicrobial therapy and poor patien outcomes this includes increased mortality.increased length of stay and ultimately,increased cost of care.staphylococcus aureus is one example in which there are multiple resistance phenotypes and multiple agents with activity against this pathogen.Currently the prevalence of meticillin resistance is ca.50-60% of all staphylocccus aureus within US medical centres.whilst vancomycinis still considered the gold standard against meticillin-resistant staphylococcus aureus.