In conclusion, postmenopausal overweight and obese Caucasian women carrying two risk
alleles for rs8050136 responded positively in terms of weight loss and CRF through moderate
intensity exercise. The weight loss benefits were greater among the A/A homozygotes who
were exposed to exercise that met, or exceeded, the physical activity recommendation.Expending energy through moderate intensity exercise among postmenopausal women
genetically predisposed to obesity is highly beneficial.