Orthorhombic paracetamol (form II) was prepared using monoclinic raw material (form I) according to Nichols and Frampton (1998), from ethanolic solution by seeding [12]. Monoclinic raw material and orthorhombic paracetamol were characterized by X-ray powder diffractometry (XRD) and used as reference samples. Mixtures of form I and II were prepared in different molar fractions and ground gently with an agate pestle and mortar. Each fraction was examined by FT-IR and FT-Raman spectroscopy and by XRD.