3.4. Perspectives for chiroptical analysis
A clear advantage of the ECD based configurational analysis is
the low amount of compound that is needed for measurements. At
the same time, aggregation effects will play the smallest role
compared to the two other chiroptical methods, ORD and VCD. In
this respect, ORD is intermediate but offers a remarkable number of
advantages: it is easy to measure; the reliability can be increased by
using short or long wavelengths; it is the only information
regarding the absolute configuration of natural products isolated in
the past, which are meanwhile decomposed and cannot be isolated
again.