In the present work, the experiments were performed according
to a central composite face-centered design. Three levels of each
independent variable (pressure, temperature and calcium hypochlorite
or carvacrol concentration) were chosen. The low, middle
and high levels of each variable were designated as 1, 0, and
+1, respectively, and are given in Table 1. Sixteen combinations
of these three variables were performed following the design (Table
2). Two replications of each experimental condition were carried
out.