CoQ10), high-density lipoprotein (26 8%), and very low-density lipoprotein intermediate-density lipoprotein (16 8%) particles (29). Normalizing CoQ10 concentra- tions for the reduction in LDL cholesterol or total choles- terol suggests that there is no change in CoQ10 lipoprotein particle concentration. For example, treatment with simva- statin 20 mg/day for 4 weeks (16) reduced serum total cholesterol and CoQ10 levels by 26% and 31%, respectively (p 0.001), but the ratio of serum CoQ10 to total cholesterol decreased only 9% (p NS). Similar apparently parallel reductions in total cholesterol have been reported by at least 7 other authors using a variety of statins (17–19,24 – 27) although 2 trials have not found reductions in circulat- ing CoQ10 levels with statin treatment (14,30).