During early stage of (+)-strand RNA viral replication,
including RV, small amounts of (-)-strand RNA are synthesized.
Templates for large-scale synthesis of (+)-strand genomic
and subgenomic RNAs are provided by newly synthesized
(-)-strand RNAs. The majority of (+)-strand RNAs
are destined for encapsidation or bound to polysomes. Under
these conditions, only a limited amount of RV (+)-strand