Considering that the interactions in the dynamic PPI networks are simultaneously obtained under the same condition, we consider that these interactions have higher quality than those in the static PPI network. Pearson correlation coefficient (PCC) is introduced to evaluate how strong two interacting proteins are co-expressed (Li et al., 2012), and GO similarity is selected to measure the functional similarity of interacting proteins. We compare the average PCC and the average GO similarity of four PPI networks which refer to the static network, our dynamic network, and two dynamic PPI networks constructed by the methods introduced by Tang et al. (2011) and Wang et al. (2013), respectively. The four networks are obtained with the same PPI data. The results are shown in Table 3. We can find that both the average PCC and GO similarity of the three dynamic PPI networks are higher than that of the static PPI network. But it is regrettable that the increase in GO similarity is generally low no matter which dynamic PPI network is compared with the static network. Nevertheless, the average PCC of dynamic networks constructed by our method and Wang’s method is much higher than that of the static network, and our dynamic network can achieve the highest PCC. Thus, we conclude that the quality of dynamic PPI networks is higher than that of the static PPI network, and the dynamic PPI network constructed by our method is relatively good.