White blood cells (WBC) or leukocytes play a significant role in the diagnosis of different diseases (including Leukemia), and therefore, extracting information about that isvaluable for hematologists. Leukemia refers to a progressive,malignant disease of the blood-forming organs. Complete blood count process is the first step for leukemia screening .The pathology is characterized by the uncontrolled accumulation of immature white blood cells. The four main types of leukemia are Acute Myelogenous Leukemia (AML); Acute Lymphoblastic Leukemia (ALL); Chronic Myeloid Leukemia (CML); Chronic Lymphocytic Leukemia (CLL). In this research, we build up a decision support tool to improve classification of Acute Myelogenous Leukemia (AML). AML is a fast-growing cancer of the blood and bone marrow.