The biomimetic two-phase strategy consisting in a cyclase phase followed by an oxidase phase have been efficiently applied to the total synthesis of complex bioactive terpenes (Ishihara and Baran, 2010). The desired oxidase phase could envisaged by biocatalytic methods, and the topic of the bio-oxidation of terpenes including both biocatalysis and whole cells biotransformations has been reviewed in 2009 (Bicas et al., 2009).