compounds. Moreover, all types of body care cosmetics applied to the skin (not only underarm cosmetics) can be a source of local estrogenic chemical input to the breast and therefore should be considered in risk assessments [14]. Gas Chromatography–Mass Spectrometry (GC–MS) is well suited for the identification of a large number of potential steroids and metabolites due to its high chromatographic resolution capacity and reproducible ionization efficiency [15]. This study was aimed to develop a simple and suitable method for the detection and quantification of paraben preservatives in human tissue using GC–MS. Silylation of parabens with MSTFA was adopted in the analysis to improve the performance of GC–MS
determination.