Purpose Hyperkalaemia due to potassium-increasing drug–drug interactions (DDIs) is a clinically important adverse drugevent. The purpose of this study was to identify patient- andphysician-related risk factors for the development ofhyperkalaemia.Methods The risk for adult patients hospitalised in theUniversity Hospital Zurich between 1 December 2009 and31 December 2011 of developing hyperkalaemia wascorrelated with patient characteristics, number, type andduration of potassium-increasing DDIs and frequency ofserum potassium monitoring.Results The 76,467 patients included in this study wereprescribed 8,413 potentially severe potassium-increasingDDIs. Patient-related characteristics associated with thedevelopment of hyperkalaemia were pulmonary allograft[relative risk (RR) 5.1; p <0.0001), impaired renal function
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