Antibiotic treatment should begin as soon as possible. Streptomycin is the drug of choice for treatment, but others, such as tetracyclines, chloramphenicol, gentamicin, or one of the sulfonamides, may also be effective. vaccine for the plague is available; however, it is only effective as a preventative measure, once someone is exposed, the vaccine will not help. The initial dose of vaccine is followed by a second one 1-3 months later and a third one 3-6 months later. Booster shots are administered at 6, 12, and 18 months and then every 1-2 years. As with all uaccines, the level of protection is related to the size of the dose, vaccination defense could be overwhelmed by extremely high doses of the bacteria