The expression of theWNK1 gene has been previously reported to be
upregulated in the postmortem prefrontal cortex from schizophrenia
sufferers [13,15], in addition to a recent report of an upregulation of
WNK1 protein expression in the hippocampus of schizophrenia sufferers
[31], thus triggering our initial interest to involve the gene of
this kinase in our study. Despite the consistently reported upregulation
of WNK1 in the prefrontal cortex of schizophrenia sufferers, no SNPs
were found to be significantly associated with schizophrenia in the
same studies [13,15,34] thus supporting the lack of significant findings
within the WNK1 gene in the present study.