The low sensitivity and specificity of most of the relevant neurologic symptoms has been largely demonstrated by several clinical trials. Prodromal stage 7 days, optic atrophy on fundal examination, focal deficit and abnormal movements were found to be independently predictive of TBM (p < 0.007) in a group of children aged 1 months to 12 years,9 but optic atrophy is usually a late occurrence and abnormal movements are rare.