Since these variables should be optimized for the development of every method, response surface
methodologies (RSM) are used to study their interactive effects on pectins extraction with good
correlation between experimental data and the predicted values. Table 2 summarizes the proposed MAE
conditions to obtain maximum pectins extraction yields from natural sources. The most usual procedure
includes the use of Box-Behnken experimental designs (BBD) or central composite designs (CCD).
Good results were reported for the extraction of target compounds, such as antioxidants from almond
skin [52], peanut skin [53] and batata leaves [54], highlighting the potential of MAE as a promising
extraction method for pectins.