Figure 2: Effect of intraperitoneal administration of methanolic
(MeOH) olive leaves extract on the carrageenan-induced rat hind
paw edema. Values are mean ± SEM. ∗P < .05, ∗∗P < .01, and
∗∗∗P < .001 versus control group, (n = 6).
4. Discussion
Both the chloroformic and methanolic extracts of olive
leaves showed a significant anti-inflammatory effect in the
acute phase of the inflammation process when compared
with the standard anti-inflammatory drugs. The effect was
observed from the first hour. The results showed that the
anti-inflammatory activity of the chloroformic extract was
more pronounced than the methanolic one.
The in vivo acute inflammation model (Carrageenaninduced
paw edema) has been frequently used to assess the
anti-inflammatory effect of natural products [10, 12]. Several
hypotheses have been advanced to explain the carrageenan