Metabolized through the liver, can result in DDIs.
Although no specific quantity recommendations are
available, moderate amounts of alcohol (2 standard
drinks in a 24-hour period) offer less concern for pharmacokinetic
and pharmacodynamic effects than larger amounts.
Grapefruit juice contains bergamottin, a natural
furanocoumarin, which can inhibit CYP3A4 and OAT.
This inhibitory effect can last for up to 24 hours. Either
grapefruit juice should be avoided with statins or the
quantity consumed should be kept to less than 60 mL.
Separating administration of grapefruit juice and statins
by 4 hours may limit the interaction.