As it has been said before, in normal condition, the corneal layer is made up of a regular assembly of corneocytes, forming a structure of modulated thickness with unique physical qualities (5).
Each corneocyte contains dampening substances called NMFs (natural moisturizing
factors), resulting from the enzymatic degradation of the fillagrines, which fix a certain
quantity of inter-corneocytar water and therefore exert a decreasing osmotic pressure as they migrate to the surface (5).
Any decrease in the enzymatic function therefore plays an important part on the NMF content and consequently on the osmotic pressure and on the opening of corneosomes, consequently easing a disorganized desquamation as it is observed with xerosis (5).