In cattle, weight loss despite adequate rations, accompanied
by chronic diarrhoea are standard clinical signs of Johne's
disease. Hypoproteinaemia and ‘bottle jaw’ or dependent
mandibular oedema, are also reported in cases of advanced
disease. However, in other species, clinical hints of the
infection may be limited to the vague and non-specific finding
of weight loss. In species with heavy coats (e.g. sheep and
llamas), this single indicator may be easily missed. Diarrhoea
is infrequently observed with paratuberculosis in sheep, goats,
bison and perhaps other non-domestic hoofstock species. In
the last phases of Johne's disease, animals of any species may
become cachectic and too weak to rise.