From the results of the present study three out of the four explanations for addition of excipients, claimed by traditional doctors and herbalists in Ghana, have been shown to be plausible. The CYP-enzyme inhibition of A. melegueta and P. guineense and the mycobacterial efflux pump inhibition of A. melegueta could increase the effect of the medicine. The odour-rich compounds of A. melegueta, P. guineense, X. aethiopica and M. myristica could most likely make the medicine more palatable. The antioxidative activityof A. melegueta could preserve the activityof the medicinal preparation over time.