Fig. 1. Histological findings in the hepatic tissues of a patient with MPV17-related hepatocerebral MDS (Patient1). A) Hepatocytes with macrovesicular steatosis (hematoxylin and eosin
stain, ×400). B) Portal inflammation with bile ductular reaction and septal fibrosis (Masson's trichrome stain, ×400). C) Hepatocytes with densely packed mitochondria showing a granular
appearance and loss of cristae (electron micrographs, ×120,000).