The results of the present study provide supporting evidence for the oxidative effect of aluminium chloride on several parameters in serum and tissues, and the ameliorating effect of Vitex doniana on aluminium chloride intoxication. This may be attributed to the time frame or duration of AlCl3 and extract administration. It is therefore concluded on the basis of previous and present study that aluminium chloride induces membrane damage and oxidative stress in tissues. Also, Vitex doniana possess ameliorating effect. Further work is however required in this study to understand the curative and preventive effect of ethanolic extracts of Vitex doniana on AlCl3 toxicity