Comparing the efficacy of garlic extract and metformin in normal and diabetic rabbits, it can be inferred that garlic extract has sufficient potential as a therapeutic agent for maintaining normoglycemia in humans as their hypoglycemic effects remained comparable in normal as well as in diabetic rabbits whose β-cell have been virtually destroyed. Such a response could possibly be due to some peripheral action of metformin as well as of garlic extract in diabetic rabbits or the administered β-cell poison was not able to destroy completely the β-cells in the given dose.