To explore the use of the MIPs as capture phases, we first focused on blood serum, which is a matrix that contains both template proteins. A method was developed based on a benchmark method by using AntiHSA antibodies or Pro- tein A affinity for the capture and depletion of these plasma proteins from blood plasma.[15] The stained gels obtained by SDS-PAGE of the native serum and the eluted fractions are shown in Figure 5. Although the MIPs fail to deplete the proteins from the sample, in contrast to the bioaffinity depletion method, the elution fractions clearly prove that the polymers can operate as capture phases. The only noticeable bands appear at identical positions as the template proteins, that is, HSA is only found in the eluate from PHSA and IgG from PIgG, whereas no detectable protein was eluted from the nonimprinted polymers.