All MS/MS spectra were searched using the Mascot®search engine (Matrix Science, Boston, MA) against the NCBI-nr database using the following criteria: enzyme trypsin,static modification of cysteine (+57.05130 Da), and differential modification of methionine (+15.99940). The search results were filtered by cross-correlation versus charge state (+1 ≥ 1.5, +2 ≥ 2.0,+3 ≥ 2.5) and protein probability (minimum 1.00E-3). The candidate protein queries were mapped to the UniProt Knowledge base(UniProtKB) [22].