Lysine has been linked to kidney failure, so do not take it if you have impaired kidney function. Large doses of lysine and other amino acids may induce acute kidney failure even in healthy individuals, according to a review published in the June 2007 issue of “The Journal of Nutrition.” Symptoms of acute kidney failure may include pain between the hip and ribs, a decrease in the amount of urine you’re excreting, intractable nausea and vomiting, and bloody stools. Seek immediate help if you develop these symptoms while taking lysine.