Release tests were carried out using the flowthrough
closed loop apparatus (Ph.Eur.) under sink
conditions. The dissolution media used were 0.1 MHCl (pH 1.1) and phosphate buffer 0.1 M (pH 7.4).
Amounts of beads equivalent to 15 mg of drug were
used and the dissolution media (500 ml) were maintained
at 37F0.5 jC throughout the study. At appropriate
intervals 5.0 ml samples were collected and
analysed using the aforementioned UV spectrophotometry
method. Each experiment was carried out in
triplicate.